"In the end, just as Indiana Jones could never turn down the opportunity to search for the Holy Grail, I could no less turn down the chance to work for myself on something I truly love, no matter how safe the alternative might be. When I’m old and dying, I plan to look back on my life and say “wow, that was an adventure,” not “wow, I sure felt safe."

Tom Preston Werner, the co-founder of GitHub, on turning down $300k from Microsoft to take a chance at his own start-up.  Check out his whole (really well written) story.